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Defines many alcohol and substance abuse words and phrases from "absolute alcohol" to "zoopsia." Published by World Health Organization.

The NCBI web site requires JavaScript to function. Comfrey has a centuries-old tradition as a medicinal plant. Today, multiple randomized controlled Drogen Thrombophlebitis have demonstrated the efficacy and safety of comfrey preparations for the topical treatment of pain, inflammation and swelling of muscles and joints Drogen Thrombophlebitis degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after sports injuries and accidents, also in children aged 3 or 4 and over.

This paper provides information on clinical trials and non-interventional studies published on comfrey to date and further literature, substantiating the fact that topical comfrey preparations are a valuable therapy option for the treatment of painful muscle and joint Drogen Thrombophlebitis. For centuries, comfrey has been used Verstoß das Recht Blutes a traditional this web page plant for the treatment of painful muscle and joint complaints Kothmann, ; Englert et al.

Commonly found throughout Europe and parts of Asia, the plant also naturalized in North America, where it rapidly spread. Native Americans also recognized its healing powers Drogen Thrombophlebitis included comfrey in their therapeutic armamentarium Hamel and Chiltoskey, ; Stammel, Comfrey has also been used in veterinary medicine Rabinovich, The German Commission E has assessed preparations containing Symphytum officinale L.

A European Scientific Cooperative on Phytotherapy Monograph is available for comfrey root Symphyti radix; ESCOP, In addition, comfrey is described in the Hager Monographs Staiger, Drogen Thrombophlebitis The constituents of comfrey root include 0. Comfrey http://24varizens.de/wunden-im-hals.php also consists of pyrrolizidine alkaloids with 1,2-unsaturated necine ring structures, almost entirely in the form of their N-oxides, the main ones being 7-acetylintermedine and 7-acetyllycopsamine together with smaller amounts Drogen Thrombophlebitis intermedine, lycopsamine and symphytine Brauchli et al.

The total amount of pyrrolizidine alkaloids given by different authors varies from 0. The pyrrolizidine alkaloids echimidine and symlandine are not found Drogen Thrombophlebitis S. Nowadays, only pyrrolizidine-depleted or pyrrolizidine-free extracts are used in proprietary medicinal products. Special cultivars are also used Schmidt, The therapeutic properties of comfrey are based on its antiinflammatory and analgesic effects. Comfrey also stimulates granulation and tissue regeneration, and supports callus formation Kommission E, ab.

However, the key activity-determining constituents of comfrey extracts and its molecular mechanisms of action have Drogen Thrombophlebitis been completely elucidated. Allantoin and rosmarinic acid are probably of central importance to its pharmacodynamic effects Drogen Thrombophlebitis et al. No clinical-pharmacokinetic investigation results in humans have been published so far on the absorption, distribution and elimination of the constituents of comfrey extracts.

Rosmarinic acid has been shown to possess antiinflammatory activity in various test systems. It inhibits the Drogen Thrombophlebitis of malondialdehyde in human platelets Gracza et al. In rat stomach preparations, a glycopeptide isolated from comfrey root dose-dependently inhibited the release of prostaglandins PGE2, PGI2, HETE and arachidonic acid.

An orally administered aqueous comfrey root extract inhibited carrageenan-induced rat paw oedema Hiermann and Writzel, Antiinflammatory properties of a dry extract from comfrey root were also demonstrated in rats with induced paw oedema Shipochliev et al. Drogen Thrombophlebitis inhibited shrinkage of the collagen matrix van den Dungen et al.

Besides the comfrey roots, all the parts of the plant that grow above ground Symphyti herba or the leaves Symphyti folium are also utilized for medical purposes Schmidt, The indications for which randomized clinical trials of ointments containing these kinds of extracts have been conducted include wound healing, myalgia and acute ankle joint distortions.

From linear regression time to complete healing was determined to be 2. The physicians rated efficacy as good to very good in A subgroup analysis found no significant influence of abrasion area, gender or age on Drogen Thrombophlebitis effects, albeit that a tendency towards better effects with increasing Drogen Thrombophlebitis was observed. No adverse effects or problems with drug tolerability were observed. This double-blind, reference-controlled, randomized, this web page trial included patients with pain in the lower and upper back.

The Drogen Thrombophlebitis efficacy parameter was pain in motion, assessed with the aid of a visual analogue scale. Secondary efficacy parameters included pain at rest, pain on palpation and functional impairment. A number needed to treat of 3. Tolerability of the highly concentrated study product was reported good to excellent in all patients. One comment on the trial emphasized that using a comparator containing very little of the active ingredient instead of a placebo might be a good approach for clinical trials with herbals, when blinding is difficult Schulz, a.

Several open and post-marketing surveillance studies have Krampfadern Preis Ekaterinburg been published. A recent study also included children 4 to 12 Drogen Thrombophlebitis of age. However, some of the read more are uncontrolled and older than 15 yr.

The symptoms pain on palpitation, pain in motion, functional impairment, oedema and haematoma were included in the evaluation.

The average duration of the administration of the trial sample was 7. The remission rates for the symptoms were No adverse drug reactions occurred. In another der trophischen Geschwüren Vitamine Informationen uncontrolled study, the efficacy of the same registered drug containing comfrey herb extract was tested on patients suffering from locomotor system symptoms Kucera et al.

The cream was applied twice daily. Functional disturbances and pain completely resolved in 57 of the patients. A further 24 patients achieved normalization of function with continued moderately severe pain. Moderate improvement occurred in 21 patients, and three patients reported no improvement in their condition.

Muscle pain proved most amenable to treatment with the cream, swelling and overstrain also responded well. The treatment was less Drogen Thrombophlebitis against pain accompanying osteoporosis. In a study involving 30 patients, the effect of the same preparation was assessed in the treatment of acute supraspinatus tendon syndrome Mayer, The ointment was combined in the form of a supplementary percutaneous therapy with local infiltration therapy during the 3-week control period.

Compared with the control group, the ointment containing comfrey extracts proved to have a significantly superior effect with regard to the reduction of pain and the associated functional restrictions. The ointment containing comfrey herb extract was also used to treat 22 additional patients suffering from acute contusions and distortions of the knee joint, and the following clinical symptoms were measured wählen richtigen wie Strümpfe für die man Krampfadern swelling of the joint, active and passive pain when moving and local pain when resting Mayer, Application of the ointment resulted in a significant Drogen Thrombophlebitis of pain after only 4 days Drogen Thrombophlebitis treatment.

All patients were completely pain-free after 10—14 days. In a 2-week controlled study, the effect of the same ointment was compared with conventional Drogen Thrombophlebitis in treating patients with acute ankle joint distortion Mayer, Test criteria in this study also included pain at rest, pain when moving and swelling. Symptoms improved significantly quicker during comfrey treatment than during cryotherapy.

Application of the ointment containing comfrey proved to be more compliance friendly than cryotherapy. In another study involving patients with acute contusions and strain traumas of the knee joint, efficacy was proven to be good or even very good and a significant therapeutic impact on the damaged joint became apparent Hess, Forty patients suffering from knee joint injuries, sprains and bruises were treated with ointment containing comfrey extract, achieving a significant reduction of pain pain at rest and http://24varizens.de/krampfadern-an-den-beinen-der-frauen-behandelt-1.php movement and swelling.

The mobility of the affected joint increased significantly. Drogen Thrombophlebitis further study examined the effect of an ointment containing Symphytum peregrinum extract in comparison with an active ingredient-free ointment base, i. The healing time when using ointment containing comfrey extract was significantly shorter than when applying comparative preparations. The difference with regard to the active ingredient-free ointment base was statistically significant.

The medicinal use of preparations from the underground parts of the plants Symphyti radix Drogen Thrombophlebitis well established. Relevant medicinal products are now marketed in more than 10 countries and the present licences include the topical treatment of pain, inflammation and swelling of muscles and joints in the case of degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after sports injuries and accidents, also in children Drogen Thrombophlebitis 3 and over.

Corresponding randomized clinical trials and non-interventional studies studied the efficacy of comfrey root extract ointment for treatment of various muscle and joint complaints Staiger, A double-blind, placebo-controlled, multicentre, randomized clinical trial with Drogen Thrombophlebitis group design was conducted over a period of 5 days Giannetti et al.

One-hundred and twenty patients with acute upper or lower Drogen Thrombophlebitis pain were treated three times a day, 4 g per application. They used Drogen Thrombophlebitis a verum cream containing comfrey root fluid extract The trial included four visits and was performed at the German Sport University in Cologne Deutsche Sporthochschule and three additional ambulatory centres for orthopaedics and sports medicine.

The primary efficacy variable was the area under the curve AUC of the Visual Analogue Scale VAS on active standardized movement values at visits 1 to 4. The pain intensity on VAS was assessed at performance of standardized, muscle group specific tests.

Drogen Thrombophlebitis secondary objectives were back Drogen Thrombophlebitis at rest using assessment by patient on VAS, pressure algometry pain—time curve; AUC over 5 daysglobal assessment Drogen Thrombophlebitis efficacy by the patient and the investigator, intake of analgesic medication and functional impairment measured with the Oswestry Disability Drogen Thrombophlebitis. There was Drogen Thrombophlebitis significant treatment difference between comfrey root extract and placebo regarding the primary and secondary variables.

The pain intensity on active standardized movement decreased on average median approximately Both the AUC of the reported back pain at rest, the AUC of the pressure algometry in the trigger point as well as the global assessment of the efficacy by the patients and Drogen Thrombophlebitis investigators showed a clinically relevant effect in reducing acute back pain.

For the first time, a fast-acting effect of the ointment 1 h was also observed. After 1 h the pain intensity had already Drogen Thrombophlebitis about A total of seven patients experienced adverse Drogen Thrombophlebitis in the course of the clinical trial, four in the comfrey extract group and three in the placebo group. All adverse events were of mild severity. One comment Drogen Thrombophlebitis the trial asked for more data in patients with different sorts of other back pain but admits that the results Drogen Thrombophlebitis relevant and topical treatment is increasingly considered as a serious treatment option Rannou, The same cream was investigated in a randomized, double-blind trial including patients suffering Drogen Thrombophlebitis painful osteoarthritis of the knee Grube et al.

All patients met the criteria of the American College of Rheumatology and Drogen Thrombophlebitis 2 g of either the active or a corresponding placebo cream three times a day for 21 days. Pain, functional impairment and stiffness are the most important symptoms patients Drogen Thrombophlebitis to relieve. Therefore, the primary target variable was the VAS sum score of Drogen Thrombophlebitis at rest and pain on movement.

A secondary target variable was the Western Ontario and McMaster Universities WOMAC score. During the course of the study, the total score of the primary target variable decreased by The secondary target criterion reduced by A total of 22 AEs occurred in 22 patients 7 in the Drogen Thrombophlebitis therapy group, 15 in the placebo group. No Drogen Thrombophlebitis drug reaction was reported in the active therapy group.

One comment on the trial mentioned the difficulties that are usually associated with the production of placebos for herbal drugs. It emphasized that due to the low inherent smell of the extract and the same perfume used in both placebo and verum, a very good blinding could be achieved for this preparation Schulz, Another comment found the trial to be well conducted and in accordance with the GCP-ICH guidelines Chrubasik, In a double-blind, multicentre, Drogen Thrombophlebitis, placebo-controlled, group comparison clinical trial on patients suffering from ankle distortion, the percutaneous efficacy of the same cream of comfrey extract was confirmed Drogen Thrombophlebitis Koll et al.

The mean age of the patients was The inclusion criterion was an uncomplicated, acute unilateral ankle distortion that had occurred no longer than 6 h previously. The duration of treatment was 8 days. Local treatment of the afflicted ankle was performed with ca. The primary variable, tenderness Drogen Thrombophlebitis the ankle joint, was measured by pressure algometry, meaning the difference in tolerated pressure Drogen Thrombophlebitis injured and healthy ankles.

Under active treatment, no adverse drug reactions were reported. A comment valued the trial as a well-executed and designed randomized clinical trial RCT with clearly shown beneficial effects De Lange-de Klerk, They applied the cream for 7 Drogen Thrombophlebitis, four times a day.

The primary efficacy variable was pain arising from pressure on the injured area, measured with a calibrated caliper algometer on days 0, 4 and 7 and evaluated by the click here under the curve AUC of the pain—time curve.

Secondary variables were the circumference of the joint Drogen Thrombophlebitis, figure-of-eight methodthe individual spontaneous pain sensation at rest and at movement according to a VAS, the global efficacy evaluation, the global assessment of tolerability and further variables. It was confirmatorily shown that comfrey extract Drogen Thrombophlebitis non-inferior to diclofenac.

The mean relative reductions in VAS in motion were Ankle swelling decreased by The pain on pressure measured with an algometer was reduced by Comments on the trial appreciated the proof of efficacy compared with the chemical comparator Schulz, b and referred to the observer-blind design Drogen Thrombophlebitis the best possible in cases where a double-blind design cannot be performed Chrubasik, Efficacy was assessed using several pain parameters: tenderness when pressure applied, pain at rest and during exercise.

The antiinflammatory potency of Drogen Thrombophlebitis extract read more found to be equal to or greater than that of diclofenac. The results of the non-interventional studies are in line with the results of the aforementioned clinical trials.

In particular, data for children aged 3 Drogen Thrombophlebitis 12 yr is available. Read article preparation was used to treat a variety of conditions such as contusions The ointment Drogen Thrombophlebitis applied to most of the children three times daily Thereby the physicians administered mostly the same dosages as for adults and Drogen Thrombophlebitis aged 12 yr and older.

In the overall score of the Drogen Thrombophlebitis pain on palpation, restriction of movement and haematoma manifestation minimum 3, maximum 15 a notable improvement in the clinical result became clear: the initial value of continue reading Clear remission or improvement was revealed in every individual finding.

The most marked reduction was in pain at rest In a post-marketing surveillance study, patients with a mean age of The median duration of treatment was During the observation period symptoms of pain at rest and during the night, pain during motion, tenderness when pressure applied, impaired mobility, painful muscle complaints and swellings improved markedly.

The use of non-steroidal antiinflammatory drugs NSAIDs was reduced or discontinued by The physicians assessed global efficacy as excellent in Most patients applied the preparation once Again, symptoms of pain at rest and pain during movement, impaired mobility, swelling and painful muscle complaints improved markedly during the observation period. Global efficacy was assessed by the physicians as excellent in A further simultaneous non-interventional study of this preparation included patients Klingenburg, In the course of the study, four patients with seven non-serious, resolved adverse events, namely skin reactions such as redness or itching, were recorded.

A total data analysis of the previous three post-marketing surveillance studies is also available Koll and Klingenburg, The findings are in line with the aforementioned results. A positive correlation could be demonstrated Wunden Gebet efficacy and the concentration of a caffeic acid derivative in the Drogen Thrombophlebitis, but not for allantoin Andres et al. With regard to safety, the absence of genotoxic effects http://24varizens.de/krampfadern-praevention-in-der-heimat.php demonstrated in the bacterial reverse mutation assay Ames test for a pyrrolizidine alkaloids PA -free comfrey root liquid extract Benedek et al.

The extract was investigated for its ability to induce gene mutations in Salmonella typhimurium strains Drogen Thrombophlebitis 98, TATATA and TA with and without metabolic activation using the mammalian microsomal fraction Drogen Thrombophlebitis mix.

Reference mutagens were used to check the validity of the experiments. The comfrey root extract showed no biologically relevant increases in revertant colony numbers of any Drogen Thrombophlebitis the five tester strains, neither in the presence nor in the absence of metabolic activation.

In conclusion, the fluid extract Drogen Thrombophlebitis not mutagenic in the bacterial reverse mutation assay. Literature on comfrey often concentrates on PAs, recommending a restriction of the duration of treatment, also with externally applied comfrey preparations. Fully licenced medicinal products available today contain depleted or PA-free Drogen Thrombophlebitis. As a consequence there are no restrictions in Die Krampfadern Behandlung Kiew Schaumverödung on these products as regards the duration of treatment Bundesgesundheitsamt, Comfrey has a long tradition as a Drogen Thrombophlebitis plant.

In general, the effects of comfrey extracts can be described as Drogen Thrombophlebitis relieving, antiinflammatory and callus formation promoting. To date, the activity-determining constituents and mechanisms of action of the medicinal plant are only partly known. However, in accordance Drogen Thrombophlebitis the modern approach of evidence-based medicine, comfrey extract creams have demonstrated their efficacy and tolerability in a number of muscle and joint injuries, such as acute myalgia in the back area, and in blunt injuries.

Comfrey herb has also been shown to be efficacious in wound healing. Comfrey root has also proven to be efficacious in activated osteoarthritis, and equivalent or more Drogen Thrombophlebitis this web page distortions compared with topical diclofenac. Although for each indication and licenced product only one modern randomized clinical trial is available so far, they all point to the pain-relieving effect in muscle and joint complaints.

It could therefore be promising to investigate topical Drogen Thrombophlebitis preparations in further indications related to muscle or joint pain, for instance chronic forms of back pain. In the 17th century, Nicholas Culpeper — mentioned comfrey in his enlarged version of The English Physitian Culpeper, Several recent randomized clinical trials substantiate the efficacy of topical comfrey preparations in the treatment of pain, Drogen Thrombophlebitis and swelling of muscles and joints in the case of degenerative Krampfadern in Kazan Preise, acute myalgia in the back, sprains, contusions and strains after sports injuries and article source, also in children aged 3 and over.

Christiane Staiger is an employee of Merck Selbstmedikation Drogen Thrombophlebitis. National Library of Medicine. NCBI Skip to main. US National Library of Medicine. National Institutes of Health Search database PMC All Databases Assembly Biocollections BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbGaP dbVar EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP Sparcle SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBook ToolKitBookgh UniGene Search term.

Journal List Wiley-Blackwell Online Open PMC Phytotherapy Research. Published online Feb Re-use of Drogen Thrombophlebitis article is permitted in accordance with the Creative Commons Deed, Attribution 2. This article has been cited by other articles in PMC.

Abstract Comfrey has a centuries-old tradition as a medicinal plant. Keywords: review, Symphytum officinale Drogen Thrombophlebitis. IN VITRO AND IN VIVO DATA Rosmarinic acid has been shown to possess antiinflammatory activity in various test systems. COMFREY HERB AND LEAVES Besides the comfrey roots, all the parts of the plant that grow above ground Symphyti herba or the leaves Symphyti folium are also utilized for medical purposes Schmidt, OTHER CLINICAL STUDIES AND POST-MARKETING SURVEILLANCE Several open and post-marketing surveillance studies have also been published.

Muscles and joints In another Drogen Thrombophlebitis uncontrolled study, the efficacy of the same registered drug containing comfrey herb extract was tested on patients suffering from locomotor system symptoms Kucera et al. Wounds A further study examined the effect of an ointment Drogen Thrombophlebitis Symphytum peregrinum extract in comparison with an active ingredient-free ointment base, i. COMFREY ROOT: RANDOMIZED CLINICAL TRIALS The medicinal use of preparations from the underground parts of the plants Read more radix is well established.

Back pain A double-blind, placebo-controlled, multicentre, randomized clinical trial with parallel group design was conducted over a period of 5 days Giannetti et al.

Painful osteoarthritis The same cream was investigated in a randomized, double-blind trial including patients suffering from painful osteoarthritis of the Drogen Thrombophlebitis Grube et al. Go here injuries In a double-blind, multicentre, randomized, placebo-controlled, group comparison clinical trial on patients suffering from ankle distortion, the percutaneous efficacy of the same cream of comfrey extract Drogen Thrombophlebitis confirmed decisively Koll et al.

POST-MARKETING SURVEILLANCE The results of the non-interventional studies are in line with the results of the aforementioned clinical trials. Comfrey cream In a post-marketing Drogen Thrombophlebitis study, patients with a mean age of Other data A total data analysis of the previous three post-marketing surveillance studies is also available Koll and Klingenburg, SAFETY With regard Drogen Thrombophlebitis safety, the absence of genotoxic effects was demonstrated in the Ursache von Krampfadern in dem Becken reverse mutation assay Ames test for a pyrrolizidine alkaloids PA -free comfrey root liquid extract Benedek Drogen Thrombophlebitis al.

DISCUSSION Comfrey has a long tradition as a medicinal plant. CONCLUSION In the 17th century, Nicholas Culpeper — mentioned comfrey in his enlarged version of The English Physitian Culpeper, Conflict of Interest Christiane Staiger is an employee of Drogen Thrombophlebitis Selbstmedikation GmbH. REFERENCES Aftab K, Shaheen F, Mohammad FV, Noorwala M, Ahmad VU. Phyto-pharmacology of saponins from Symphytum officinale L.

Adv Exp Med Biol. Klinische und instrumentalanalytische Untersuchung von Dermatika mit Extrakten aus Symphytum officinale L. Dissertation, University of Bern. Andres P, Brenneisen R, Clerc JT. Drogen Thrombophlebitis antiphlogistic efficacy of dermatics containing extracts of Symphytum officinale to chemical profiles.

London: Pharmaceutical Press; Benedek B, Ziegler A, Ottersbach P. Absense of mutagenic effects of a particular Symphytum officinale L. Pyrrolizidine alkaloids from Symphytum officinale L. Vom 5, Bundesanzeiger No. Poliklinische Anwendung von Kytta Plasma und Kytta Salbe. Comparison of local Symphytum officinale L. Focus Altern Complement Ther. Effectiveness of Symphytum officinale comfrey root extract ointment in painful knee osteoarthritis. Points to Consider on Switching Between Superiority and Non-inferiority.

The English Physitian enlarged: With Three Hundred, Sixty, and Drogen Thrombophlebitis Medicines, made of English Herbs that are not in any Impression until this: The Epistle will inform you how to know This impression from any other. Being an Astrologo-Physical Discourse of the Vulgar Herbs of this Nation. Containing a Compleat Method or Physick, whereby a man may preserve his Body in health; or Cure himself, being Sick, for three pence Charge, with such things only as grow in England, they being most fit for English Bodies.

London: Peter Cole; Comfrey extract ointment in comparison to a diclofenac gel in the treatment of acute unilateral ankle sprains distortions Arzneim-Forsch Drug Res. Symphytum officinale comfrey ointment relieves pain and swelling after ankle distortion. Dennis R, Dezelak C, Grime J. Studies on Symphytum species — HPLC determination of allantoin.

ESCOP Monographs: Drogen Thrombophlebitis Scientific Foundation for Herbal Medicinal Products. Stuttgart: European Scientific Cooperative on Phytotherapy, Thieme Verlag; Symphyti radix, Comfrey Drogen Thrombophlebitis pp. Efficacy and safety of a comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial.

Br J Sport Med. Phenolic acids in Symphytum officinale Click to see more. Efficacy of a comfrey root Symphyti offic.

Hamel PB, Chiltoskey MU. Their uses Drogen Thrombophlebitis a year history. Sylva, NC: Herald Publishers; Wirkung einer Symphytum-Salbe bei Sportverletzungen des Kniegelenks. Hiermann A, Writzel M. Antiphlogistic glycopeptide from the roots source Symphytum officinale.

Koehler H, Franz G. Symphytum officinale — Beinwell. Koll R, Klingenburg S. Ergebnisse einer multizentrischen, randomisierten, placebo-kontrollierten Doppelblindstudie. Koll R, Buhr M, Dieter R, et al. Drogen Thrombophlebitis and tolerance of a comfrey root extract Extr. Symphyti in the treatment of ankle distortions: results of a multicenter, randomized, placebo-controlled, double-blind study.

Monographie Symphyti radix Beinwellwurzel. Korte H, Rapp G. Beinwell — Wirkungsgeschichte und Bedeutungswandel einer Heilpflanze. Kucera M, Kalal J, Polesna Z. Effects of Symphytum ointment on muscular symptoms and functional locomotor disturbances. Efficacy and safety of topical applied Symphytum herb extract cream in the treatment of ankle distorsion: Results of a randomized controlled clinical double-blind study.

Topical symphytum herb concentrate cream against myalgia. A randomized controlled double blind clinical study. Biological screening of Italian medicinal plants for anti-inflammatory activity. Die Lokalbehandlung der akuten lateralen Distorsion des oberen Sprunggelenkes mit einer Symphytum-Wirkstoffkomplex-Salbe. Die Lokalbehandlung von Kontusionen und Distorsionen des Kniegelenkes mit einer Symphytum-Wirkstoffkomplex-Salbe. Die Lokalbehandlung des akuten Supraspinatussehnen-Syndroms mit einer Symphytum-Wirkstoffkomplex-Salbe.

Untersuchungen zum Pyrrolizidinalkaloidgehalt und Pyrrolizidinalkaloidmuster in Symphytum officinale L. Versuche zur Gewinnung pyrrolizidinalkaloidarmer Pflanzen bzw. HPLC-Analytik der Pyrrolizidin-Alkaloide von Symphytum Drogen. Beeinflussung der Epithelialisierung durch einen Wirkstoffkomplex aus Symphytum.

Pabst H, Ottersbach P. Topikum Drogen Thrombophlebitis Muskel- und Gelenkbeschwerden. Anti-inflammatory activity of see more pyrrolizidine alkaloid-free extract of roots of Symphytum officinale in humans.

Predel HG, Giannetti B, Koll R, Bulitta M, Staiger C. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in Drogen Thrombophlebitis of ankle distortions: results of an observer-blind, randomized, multicenter study.

Symphytum in der Praxis. Medicinal Plants in the Veterinary Medicine. Moscow: Russagricultural Publishing House; Is Symphytum officinale comfrey root extract ointment useful in the treatment of back pain?

Beinwellsalbe bei stumpfen Traumen und Muskelschmerzen. Beinwell-Creme lindert akute Beschwerden nach Sprungelenksdistorsion.

Doppelblindstudie bei Patienten belegt signifikante Behandlungserfolge. Wirksamkeit einer Beinwell-Salbe im Vergleich mit Placebo bei Drogen Thrombophlebitis mit Osteoarthritis des Kniegelenkes.

Shipochliev T, Dimitrov A, Aleksandrova E. Beinwell — eine moderne Arzneipflanze. Beinwell — Stand der klinischen Forschung. In: Blaschek W, Ebel S, Hackenthal E, et al. Drogen Thrombophlebitis C, Wegener T. Beinwell in der Therapie stumpfer Traumen: Anwendung bei Kindern. Das medizinische Wissen der Indianer und ihre Heilpflanzen. Stengl P, Wiedenfeld H, Roeder E. Pyrrolizidine alkaloids: testing for toxic constituents of comfrey.

Teuscher E, Willuhn G, Loew D. Symphyti radix visit web page Beinwellwurzel. In: Wichtl M, editor. Stuttgart: Wissenschaftliche Verlagsgesellschaft; Tittel G, Hinz H, Wagner H. Quantitative determination of pyrrolizidine alkaloids in Symphyti Radix by HPLC. Van den Dungen FM. Influence on immune functions and wound-healing processes.

Van den Dungen FM, Fischer FC, Souren JEM, Labadie RP. Drogen Thrombophlebitis effect of some Symphytum officinale tincture fractions on the shrinking of a collagen matrix by fibroblasts.

Pharm Weekbl Sci Ed. Vollmer J, Steiner N, Larsen G, Muirhead K, Molyneux R. Aqueous extract of Symphytum officinale in the treatment of some skin diseases in infants. Formats: Article PubReader verstärkt Prellungen Varizen starke beta PDF K Citation Share. Please review our privacy policy. Policies and Guidelines Contact.


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